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Article

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.

PLoS biology - 1 Oct 2015

Bacaj Taulant, Wu Dick, Burré Jacqueline, Malenka Robert C, Liu Xinran, Südhof Thomas C

Abstract excerpt

In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively. Loss-of-function of synaptotagmin-1 or -7 selectively impairs the fast and slow phase of release, respectively, but does not change the size of the readily-releasable pool (RRP) of vesicles as measured by stimulation of release with...

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PMID: 26437117
DOI: 10.1371/journal.pbio.1002267
PMCID: PMC4593569

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