Size of vesicle pools, rates of mobilization, and recycling at neuromuscular synapses of a Drosophila mutant, shibire.

doi:10.1016/s0896-6273(00)00165-3

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Article

Size of vesicle pools, rates of mobilization, and recycling at neuromuscular synapses of a Drosophila mutant, shibire.

Neuron - 1 Dec 2000

Delgado R, Maureira C, Oliva C, Kidokoro Y, Labarca P

Abstract excerpt

Two vesicle pools, readily releasable (RRP) and reserve (RP) pools, are present at Drosophila neuromuscular junctions. Using a temperature-sensitive mutant, shibire(ts), we studied pool sizes and vesicle mobilization rates. In shibire(ts), due to lack of endocytosis at nonpermissive temperatures, synaptic currents continuously declined during tetanic stimulation until they ceased as the result of vesicle...

Topics

Animals
Cytochalasin D
Drosophila
Drosophila Proteins
Dynamins
Electric Stimulation
Endocytosis
Fluorescent Dyes
GTP Phosphohydrolases
Mutation
Neuromuscular Junction
Pyridinium Compounds
Quaternary Ammonium Compounds
Synaptic Transmission
Synaptic Vesicles
Temperature

Source

Open in PubMed

Identifiers

PMID: 11163278
DOI: 10.1016/s0896-6273(00)00165-3

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