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Article

Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase α to schizophrenia.

Biological psychiatry - 1 Oct 2011

Takahashi Nagahide, Nielsen Karin Sandager, Aleksic Branko, Petersen Steffen, Ikeda Masashi, Kushima Itaru, Vacaresse Nathalie, Ujike Hiroshi, Iwata Nakao, Dubreuil Véronique, Mirza Naheed, Sakurai Takeshi, Ozaki Norio, Buxbaum Joseph D, Sap Jan

Abstract excerpt

BACKGROUND: Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPα, in the control of radial neuronal migration, cortical cytoarchitecture, and oligodendrocyte differentiation. The human gene encoding RPTPα, PTPRA, maps to a chromosomal region...

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Identifiers

PMID: 21831360
DOI: 10.1016/j.biopsych.2011.06.016
PMCID: PMC3176920

Genes

PTPRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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