Article
Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.
Molecular brain - 22 Jan 2021
Hada Kazuhiro, Wulaer Bolati, Nagai Taku, Itoh Norimichi, Sawahata Masahito, Sobue Akira, Mizoguchi Hiroyuki, Mori Daisuke, Kushima Itaru, Nabeshima Toshitaka, Ozaki Norio, Yamada Kiyofumi
Abstract excerpt
We recently found a significant association between exonic copy-number variations in the Rho GTPase activating protein 10 (Arhgap10) gene and schizophrenia in Japanese patients. Special attention was paid to one patient carrying a missense variant (p.S490P) in exon 17, which overlapped with an exonic deletion in the other allele. Accordingly, we generated a mouse model (Arhgap10 S490P/NHEJ mice) carrying a...
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