Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation of the catalytic phosphatase domain of PTPRT/RPTPρ increases social interaction in mice.

Autism research : official journal of the International Society for Autism Research - 1 Feb 2015

Thirtamara Rajamani Keerthi, O'Neill Brian, Han Dawn D, Frostholm Adrienne, Rotter Andrej, Gu Howard H

Abstract excerpt

Receptor protein tyrosine phosphatase rho (RPTPρ, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum. It has an extracellular domain that interacts with other cell adhesion molecules, and it has two intracellular phosphatase domains, one of which is catalytically active. In a recent genome-wide association study, PTPRT was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 24895325
DOI: 10.1002/aur.1390
PMCID: PMC8970463

Genes

PTPRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of the catalytic phosphatase domain of PTPRT/RPTPρ increases social interaction in mice.PMID 24895325Read ↗

Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase α to schizophrenia.Semantic proximity Read ↗

Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder inTspan7knockout ratsSemantic proximity Read ↗

Characterization of PTPRG in knockdown and phosphatase-inactive mutant mice and substrate trapping analysis of PTPRG in mammalian cells.Semantic proximity Read ↗

Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation.Semantic proximity Read ↗

Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice.Semantic proximity Read ↗

Reduced PTPRD expression differentially alters brain phosphotyrosine phosphoproteomic profiles of 2 and 12 month-old miceSemantic proximity Read ↗

Genetic disruption of leucine rich repeat transmembrane protein 4 like 1 induces a pro-social behavioural phenotype in zebrafishSemantic proximity Read ↗

Inhibition of protein tyrosine phosphatase PTP1B function ameliorates pathophysiological deficits in Rett SyndromeSemantic proximity Read ↗

Abnormal social behaviors and altered gene expression rates in a mouse model for Potocki-Lupski syndrome.Semantic proximity Read ↗

Genetic disruption of leucine rich repeat transmembrane protein 4 like 1 induces a pro-social behavioural phenotype in zebrafish.Semantic proximity Read ↗

Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice.Semantic proximity Read ↗

Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.