Article
Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene.
Pharmacological research - 1 Jan 2023
Tanaka Rinako, Liao Jingzhu, Hada Kazuhiro, Mori Daisuke, Nagai Taku, Matsuzaki Tetsuo, Nabeshima Toshitaka, Kaibuchi Kozo, Ozaki Norio, Mizoguchi Hiroyuki, Yamada Kiyofumi
Abstract excerpt
Copy-number variations in the ARHGAP10 gene encoding Rho GTPase-activating protein 10 are associated with schizophrenia. Model mice (Arhgap10 S490P/NHEJ mice) that carry "double-hit" mutations in the Arhgap10 gene mimic the schizophrenia in a Japanese patient, exhibiting altered spine density, methamphetamine-induced cognitive dysfunction, and activation of RhoA/Rho-kinase signaling. However, it remains unclear...
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