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Article

A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.

Nature genetics - 1 Nov 2002

Harroch Sheila, Furtado Glaucia C, Brueck Wolfgang, Rosenbluth Jack, Lafaille Juan, Chao Moses, Buxbaum Joseph D, Schlessinger Joseph

Abstract excerpt

Several lines of evidence suggest that tyrosine phosphorylation is a key element in myelin formation, differentiation of oligodendrocytes and Schwann cells, and recovery from demyelinating lesions. Multiple sclerosis is a demyelinating disease of the human central nervous system, and studies of experimental demyelination indicate that remyelination in vivo requires the local generation, migration or maturation of...

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Share to Cell Separation
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12355066
DOI: 10.1038/ng1004

Genes

MOG
PTPRZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.PMID 12355066Read ↗

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