Article
LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease.
Molecular and cellular neurosciences - 1 Dec 2003
Harrison S M, Reavill C, Brown G, Brown J T, Cluderay J E, Crook B, Davies C H, Dawson L A, Grau E, Heidbreder C, Hemmati P, Hervieu G, Howarth A, Hughes Z A, Hunter A J, Latcham J, Pickering S, Pugh P, Rogers D C, Shilliam C S, Maycox P R
Abstract excerpt
Several psychiatric diseases, including schizophrenia, are thought to have a developmental aetiology, but to date no clear link has been made between psychiatric disease and a specific developmental process. LPA(1) is a G(i)-coupled seven transmembrane receptor with high affinity for lysophosphatidic acid. Although LPA(1) is expressed in several peripheral tissues, in the nervous system it shows relatively...
Topics
- Animals
- Brain
- Female
- Male
- Mental Disorders
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Reaction Time
- Receptors, G-Protein-Coupled
- Receptors, Lysophosphatidic Acid
- Reflex, Startle