Article
Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease.
Inflammatory bowel diseases - 1 Sept 2011
Glas Jürgen, Seiderer Julia, Fischer Daniel, Tengler Barbara, Pfennig Simone, Wetzke Martin, Beigel Florian, Olszak Torsten, Weidinger Maria, Göke Burkhard, Ochsenkühn Thomas, Folwaczny Matthias, Müller-Myhsok Bertram, Diegelmann Julia, Czamara Darina, Brand Stephan
Abstract excerpt
BACKGROUND: The pregnane X receptor (PXR/NR1I2) is an important regulator of xenobiotic metabolism and intestinal integrity. However, there are controversial studies on the role of PXR/NR1I2 in inflammatory bowel disease (IBD). We therefore initiated the largest analysis to date on PXR/NR1I2 gene variants in IBD patients. METHODS: Genomic DNA from 2823 individuals of Caucasian origin including 859 patients with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.