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Article

Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach.

Inflammatory bowel diseases - 1 Sept 2008

Amre Devendra K, Mack David R, Israel David, Morgan Kenneth, Krupoves Alfreda, Costea Irina, Lambrette Philippe, Grimard Guy, Deslandres Colette, Levy Emile, Seidman Ernest G

Abstract excerpt

BACKGROUND: The pregnane-X-receptor (PXR) is involved in the metabolism and detoxification of numerous xenobiotics and is critical for maintaining intestinal integrity. The NR1I2 gene encoding PXR may confer susceptibility for Crohn's disease (CD) but evidence for associations is conflicting. We investigated whether the NR1I2 gene was associated with susceptibility for pediatric CD. METHODS: A case-control and...

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PMID: 18381611
DOI: 10.1002/ibd.20461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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