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Article

Genetic variation in the farnesoid X-receptor predicts Crohn's disease severity in female patients.

Scientific reports - 16 Jul 2020

Wilson Aze, Wang Qian, Almousa Ahmed A, Jansen Laura E, Choi Yun-Hee, Schwarz Ute I, Kim Richard B

Abstract excerpt

The farnesoid X receptor (FXR) is implicated in Crohn's disease (CD) pathogenesis. It is unclear how genetic variation in FXR impacts CD severity versus genetic variation in nuclear receptors such as pregnane X receptor (PXR) and the multi-drug resistance protein 1 (MDR1, ABCB1). To evaluate FXR-1G > T as a genomic biomarker of severity in CD and propose a plausible molecular mechanism. A retrospective study...

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Identifiers

PMID: 32678214
DOI: 10.1038/s41598-020-68686-9
PMCID: PMC7366697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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