Article
The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease.
Gastroenterology - 1 Feb 2006
Dring Megan M, Goulding Carol A, Trimble Valerie I, Keegan Denise, Ryan Anthony W, Brophy Karen M, Smyth Claire M, Keeling P W Napoleon, O'Donoghue Diarmuid, O'Sullivan Maria, O'Morain Colm, Mahmud Nasir, Wikström Ann-Charlotte, Kelleher Dermot, McManus Ross
Abstract excerpt
BACKGROUND & AIMS: The pregnane X receptor (PXR) regulates an array of genes involved in the response to xenobiotics. Evidence from several studies suggests that xenobiotic metabolism may play a role in inflammatory bowel disease (IBD) and that low levels of PXR may be associated with disease expression. The aim of this study was to investigate the association of functional polymorphisms of the PXR encoding gene...
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