Article
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
PLoS genetics - 1 Aug 2011
Fehrmann Rudolf S N, Jansen Ritsert C, Veldink Jan H, Westra Harm-Jan, Arends Danny, Bonder Marc Jan, Fu Jingyuan, Deelen Patrick, Groen Harry J M, Smolonska Asia, Weersma Rinse K, Hofstra Robert M W, Buurman Wim A, Rensen Sander, Wolfs Marcel G M, Platteel Mathieu, Zhernakova Alexandra, Elbers Clara C, Festen Eleanora M, Trynka Gosia, Hofker Marten H, Saris Christiaan G J, Ophoff Roel A, van den Berg Leonard H, van Heel David A, Wijmenga Cisca, Te Meerman Gerard J, Franke Lude
Abstract excerpt
For many complex traits, genetic variants have been found associated. However, it is still mostly unclear through which downstream mechanism these variants cause these phenotypes. Knowledge of these intermediate steps is crucial to understand pathogenesis, while also providing leads for potential pharmacological intervention. Here we relied upon natural human genetic variation to identify effects of these...
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