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Article

Trans-eQTLs identified in whole blood have limited influence on complex disease biology.

European journal of human genetics : EJHG - 1 Sept 2018

Yap Chloe X, Lloyd-Jones Luke, Holloway Alexander, Smartt Peter, Wray Naomi R, Gratten Jacob, Powell Joseph E

Abstract excerpt

Trans-eQTLs have been implicated in complex traits and common diseases, but many were initially identified on the basis of having an effect in cis, and there has been no assessment of the significance of the overlap in relation to chance expectations. Here, we investigated whether trans-expression quantitative trait loci (eQTL) associations identified in whole blood contribute to variance in complex traits by...

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Identifiers

PMID: 29891877
DOI: 10.1038/s41431-018-0174-7
PMCID: PMC6117341

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