Escherichia coli mutant trpA34 has an Asp----Asn change at active site residue 60 of the tryptophan synthetase alpha chain.

Abstract excerpt

Asp-60 is believed to be a catalytically essential residue of the tryptophan synthetase alpha chain of Escherichia coli (Nagata, S., Hyde, C.C., and Miles, E.W. (1989) J. Biol. Chem. 264, 6288-6296). Surprisingly, mutations altering Asp-60 were not observed in the many trpA missense mutants characterized in the 1960s. However, there was one genetic class of trpA missense mutants, represented by trpA34, for which...

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