Structural and kinetic analysis of a channel-impaired mutant of tryptophan synthase.

Article

Structural and kinetic analysis of a channel-impaired mutant of tryptophan synthase.

The Journal of biological chemistry - 28 Oct 1994

Schlichting I, Yang X J, Miles E W, Kim A Y, Anderson K S

Abstract excerpt

Substrate channeling is a process by which two sequential enzymes interact to transfer a metabolite (or intermediate) from one enzyme active site to the next without allowing free diffusion of the metabolite. Channeling is thought to play an important role in metabolic regulation and cellular mod...

Topics

Catalysis
Crystallography, X-Ray
Glycerophosphates
Indoles
Kinetics
Models, Molecular
Mutation
Salmonella typhimurium
Serine
Tryptophan
Tryptophan Synthase

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