Article
Structures of wild-type and P28L/Y173F tryptophan synthase alpha-subunits from Escherichia coli.
Biochemical and biophysical research communications - 29 Oct 2004
Jeong Mi Suk, Jeong Jae Kap, Lim Woon Ki, Jang Se Bok
Abstract excerpt
The alpha-subunit of tryptophan synthase (alphaTS) catalyzes the cleavage of indole-3-glycerol phosphate to glyceraldehyde-3-phosphate and indole, which is used to yield the amino acid tryptophan in tryptophan biosynthesis. Here, we report the first crystal structures of wild-type and double-mutant P28L/Y173F alpha-subunit of tryptophan synthase from Escherichia coli at 2.8 and 1.8A resolution, respectively. The...
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