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Article

Elucidation of information encoded in tryptophan 140 of staphylococcal nuclease.

Proteins - 1 Feb 2005

Hirano Satoshi, Kamikubo Hironari, Yamazaki Yoichi, Kataoka Mikio

Abstract excerpt

We investigated the role of W140 in the folding of Staphylococcal nuclease. For this purpose, we constructed the 19 possible substitution mutations at residue 140. Only three mutants, W140F, W140H, and W140Y, adopted native-like structures under physiological conditions and showed native-like enzymatic activities. In contrast, the other 16 mutants took on compact unfolded structures under physiological conditions...

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Identifiers

PMID: 15573380
DOI: 10.1002/prot.20333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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