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Article

Analysis of the NH2-terminal 87th amino acid of Escherichia coli GyrA in quinolone-resistance.

Microbiology and immunology - 1 Jan 1995

Yonezawa M, Takahata M, Banzawa N, Matsubara N, Watanabe Y, Narita H

Abstract excerpt

The functional contributions of amino acid residue Asp87 of Escherichia coli gyrase A protein (GyrA) was analyzed by site-directed mutagenesis. We generated a series of mutants, in which Asp87 of GyrA was changed to Ala, Val, Phe, Asn, Ser, and Lys. By genetic analysis of gyrA genes in a gyrA temperature-sensitive (Ts) background, it was shown that all these mutations caused the quinolone-resistance. These...

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PMID: 8569537
DOI: 10.1111/j.1348-0421.1995.tb02236.x

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