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Article

Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a.

The Journal of cell biology - 30 Oct 2000

Barbieri M A, Roberts R L, Gumusboga A, Highfield H, Alvarez-Dominguez C, Wells A, Stahl P D

Abstract excerpt

Activated epidermal growth factor receptors recruit various intracellular proteins leading to signal generation and endocytic trafficking. Although activated receptors are rapidly internalized into the endocytic compartment and subsequently degraded in lysosomes, the linkage between signaling and endocytosis is not well understood. Here we show that EGF stimulation of NR6 cells induces a specific, rapid and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11062256
DOI: 10.1083/jcb.151.3.539
PMCID: PMC2185585

Genes

EGF
EGFR
EEA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a.PMID 11062256Read ↗

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