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Article

Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.

Molecular and cellular biology - 1 Dec 2005

Giri Dipak K, Ali-Seyed Mohamed, Li Long-Yuan, Lee Dung-Fang, Ling Pin, Bartholomeusz Geoffrey, Wang Shao-Chun, Hung Mien-Chie

Abstract excerpt

The cell membrane receptor ErbB-2 migrates to the nucleus. However, the mechanism of its nuclear translocation is unclear. Here, we report a novel mechanism of its nuclear localization that involves interaction with the transport receptor importin beta1, nuclear pore protein Nup358, and a host of players in endocytic internalization. Knocking down importin beta1 using small interfering RNA oligonucleotides or...

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Identifiers

PMID: 16314522
DOI: 10.1128/MCB.25.24.11005-11018.2005
PMCID: PMC1316946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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