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Article

A recombinant mutant abrin A chain expressed in Escherichia coli can be used as an effective vaccine candidate.

Human vaccines - 1 Aug 2011

Han Yan-Hui, Gao Shan, Xin Wen-Wen, Kang Lin, Wang Jing-Lin

Abstract excerpt

We used site-directed mutagenesis to mutate two key amino acid residues, Glu164 and Arg167, of abrin A chain (ABRA), creating a mutant ABRA(E164AR167L). The mutant ABRA(mABRA) encoded by mABRA(E164AR167L) was expressed in the cytoplasm of Escherichia coli, and used to develop an effective vaccine to protect mice against native abrin intoxication. The cytotoxicity of mABRA was dramatically reduced as compared to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21817853
DOI: 10.4161/hv.7.8.16258

Genes

ABRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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