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Article

Immunogenicity of the histidine-to-tyrosine staphylococcal enterotoxin B mutant protein in C3H/HeJ mice.

Toxicon : official journal of the International Society on Toxinology - 15 Mar 2004

Savransky Vladimir, Pinelis Dmitriy, Korolev Sergey, Ionin Boris, Fegeding Konstantin

Abstract excerpt

Staphylococcal enterotoxin B (SEB) is a common cause of food poisoning and toxic shock. A safe and effective vaccine is needed to protect against the superantigenic effects of this toxin. We previously constructed and produced an apparently nontoxic SEB mutant having four histidine-to-tyrosine substitutions in positions 12, 32, 105, and 121. In the present study, we found that this H1.2.3.4 SEB mutant had low...

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Identifiers

PMID: 15051407
DOI: 10.1016/j.toxicon.2004.02.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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