Non-toxic derivatives of LT as potent adjuvants.

doi:10.1016/j.vaccine.2010.11.091

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Article

Non-toxic derivatives of LT as potent adjuvants.

Vaccine - 11 Feb 2011

da Hora Vanusa P, Conceição Fabricio R, Dellagostin Odir A, Doolan Denise L

Abstract excerpt

The heat-labile enterotoxin of Escherichia coli (LT) consists of an enzymatically active A subunit (LTA) and a pentameric B subunit (LTB). LT has been extensively studied as a potent modulator of immune responses but wild-type LT is toxic and therefore unsuitable for clinical use. Approaches pursued to avoid the toxicity associated with the use of the native toxin while retaining its adjuvant properties have...

Topics

Adjuvants, Immunologic
Animals
Bacterial Toxins
Enterotoxins
Escherichia coli
Escherichia coli Proteins
Humans
Immunomodulation
Mutation
Recombinant Proteins

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Open in PubMed

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PMID: 21163247
DOI: 10.1016/j.vaccine.2010.11.091

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