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Article

Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Aug 2011

Verges Deborah K, Restivo Jessica L, Goebel Whitney D, Holtzman David M, Cirrito John R

Abstract excerpt

The concentration of amyloid-β (Aβ) within the brain extracellular space is one determinant of whether the peptide will aggregate into toxic species that are important in Alzheimer's disease (AD) pathogenesis. Some types of synaptic activity can regulate Aβ levels. Here we demonstrate two distinct mechanisms that are simultaneously activated by NMDA receptors and regulate brain interstitial fluid (ISF) Aβ levels...

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Source

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Identifiers

PMID: 21813692
DOI: 10.1523/JNEUROSCI.0607-11.2011
PMCID: PMC3329800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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