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Article

Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes.

Cell reports - 5 Jul 2017

Haas Laura T, Salazar Santiago V, Smith Levi M, Zhao Helen R, Cox Timothy O, Herber Charlotte S, Degnan Andrew P, Balakrishnan Anand, Macor John E, Albright Charles F, Strittmatter Stephen M

Abstract excerpt

Metabotropic glutamate receptor 5 (mGluR5) has been implicated in Alzheimer's disease (AD) pathology. We sought to understand whether mGluR5's role in AD requires glutamate signaling. We used a potent mGluR5 silent allosteric modulator (SAM, BMS-984923) to separate its well-known physiological role in glutamate signaling from a pathological role in mediating amyloid-β oligomer (Aβo) action. Binding of the SAM to...

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Identifiers

PMID: 28683325
DOI: 10.1016/j.celrep.2017.06.023
PMCID: PMC5547898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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