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Article

AMPA receptor downscaling at the onset of Alzheimer’s disease pathology in double knockin mice

21 Feb 2006

Abstract excerpt

It is widely thought that Alzheimer's disease (AD) begins as a malfunction of synapses, eventually leading to cognitive impairment and dementia. Homeostatic synaptic scaling is a mechanism that could be crucial at the onset of AD but has not been examined experimentally. In this process, the synaptic strength of a neuron is modified so that the overall excitability of the cell is maintained. Here, we investigate...

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Identifiers

PMID: 16492745
DOI: 10.1073/pnas.0507313103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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