Article
Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors.
Journal of neurochemistry - 1 Jun 2009
Wheeler David, Knapp Edward, Bandaru Veera V R, Wang Yue, Knorr David, Poirier Christophe, Mattson Mark P, Geiger Jonathan D, Haughey Norman J
Abstract excerpt
The insertion and removal of NMDA receptors from the synapse are critical events that modulate synaptic plasticity. While a great deal of progress has been made on understanding the mechanisms that modulate trafficking of NMDA receptors, we do not currently understand the molecular events required for the fusion of receptor containing vesicles with the plasma membrane. Here, we show that sphingomyelin...
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