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Article

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.

Neuron - 7 Dec 2006

Hsieh Helen, Boehm Jannic, Sato Chihiro, Iwatsubo Takeshi, Tomita Taisuke, Sisodia Sangram, Malinow Roberto

Abstract excerpt

Beta amyloid (Abeta), a peptide generated from the amyloid precursor protein (APP) by neurons, is widely believed to underlie the pathophysiology of Alzheimer's disease. Recent studies indicate that this peptide can drive loss of surface AMPA and NMDA type glutamate receptors. We now show that Ab...

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Source

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Identifiers

PMID: 17145504
DOI: 10.1016/j.neuron.2006.10.035
PMCID: PMC1850952

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17145504-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.PMID 17145504Read ↗

AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive agingSemantic proximity Read ↗

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NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²⁺-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin.Semantic proximity Read ↗

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