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Article

Expression and replication timing patterns of wildtype and translocated BCL2 genes.

Genomics - 15 Apr 2001

Sun Y, Wyatt R T, Bigley A, Krontiris T G

Abstract excerpt

Translocation of the BCL2 gene from chromosome 18 to chromosome 14 results in constitutive expression of the gene. We have recently demonstrated that the major breakpoint region (mbr) of BCL2, which is implicated in 70% of t(14;18) translocations present in human follicular lymphoma, is a matrix attachment region. Since these regions are implicated in control of both transcription and replication, we wished to...

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Share to Cell Cycle
Share to Chromosomes, Human, Pair 14
Share to Chromosomes, Human, Pair 18

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to In Situ Hybridization, Fluorescence

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-bcl-2

Share to Translocation, Genetic

Source

Identifiers

PMID: 11318606
DOI: 10.1006/geno.2000.6479

Genes

BCL2
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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