Article
Expression and replication timing patterns of wildtype and translocated BCL2 genes.
Genomics - 15 Apr 2001
Sun Y, Wyatt R T, Bigley A, Krontiris T G
Abstract excerpt
Translocation of the BCL2 gene from chromosome 18 to chromosome 14 results in constitutive expression of the gene. We have recently demonstrated that the major breakpoint region (mbr) of BCL2, which is implicated in 70% of t(14;18) translocations present in human follicular lymphoma, is a matrix attachment region. Since these regions are implicated in control of both transcription and replication, we wished to...
Topics
- Alleles
- Cell Cycle
- Cell Line
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 18
- DNA Replication
- DNA, Neoplasm
- Flow Cytometry
- Gene Expression Regulation, Neoplastic
- Humans
- In Situ Hybridization, Fluorescence
- Polymerase Chain Reaction
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Proto-Oncogene Proteins c-bcl-2
- Transcription, Genetic
- Translocation, Genetic