Article
N-Ethyl-N-nitrosourea induces mammary cancers in the pituitary-isografted mouse which are histologically and genotypically distinct from those induced by N-methyl-N-nitrosourea.
Cancer letters - 19 Apr 1996
Swanson S M, Guzman R C, Tsukamoto T, Huang T T, Dougherty C D, Nandi S
Abstract excerpt
N-Ethyl-N-nitrosourea (ENU) and N-methyl-N-nitrosourea (MNU) are alkylating agents which respectively ethylate or methylate nucleophilic centers in the cell such as DNA. In vitro studies with naked DNA and bacterial mutagenesis assays suggest that these two compounds induce different spectra of g...
Topics
- Animals
- Base Sequence
- Carcinogens
- Cocarcinogenesis
- Ethylnitrosourea
- Female
- Gene Expression Regulation, Neoplastic
- Genotype
- Mammary Neoplasms, Experimental
- Methylnitrosourea
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Pituitary Gland, Anterior