Article
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.
Cancer research - 15 May 2000
Omer C A, Chen Z, Diehl R E, Conner M W, Chen H Y, Trumbauer M E, Gopal-Truter S, Seeburger G, Bhimnathwala H, Abrams M T, Davide J P, Ellis M S, Gibbs J B, Greenberg I, Koblan K S, Kral A M, Liu D, Lobell R B, Miller P J, Mosser S D, O'Neill T J, Rands E, Schaber M D, Senderak E T, Oliff A, Kohl N E
Abstract excerpt
For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction catalyzed by the enzyme farnesyl:protein transferase (FPTase). Inhibitors of FPTase have therefore been developed as potential anticancer agents. These compounds reverse many of the malignant phenotypes of Ras-transformed cells in culture and inhibit the growth of tumor xenografts in...
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