N-methylnitrosourea-induced Ki-ras codon 12 mutations: early events in mouse thymic lymphomas.

doi:10.1002/mc.2940130205

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Article

N-methylnitrosourea-induced Ki-ras codon 12 mutations: early events in mouse thymic lymphomas.

Molecular carcinogenesis - 1 Jun 1995

Newcomb E W, Bayona W, Pisharody S

Abstract excerpt

N-Methylnitrosourea (NMU)-induced codon 12 Ki-ras mutations were analyzed in premalignant thymic lymphomas from C57BL/6J mice by using a selective polymerase chain reaction amplification strategy. The frequency of codon 12 Ki-ras mutations was 67% (16 of 24) in NMU-treated animals with premaligna...

Topics

Animals
Base Sequence
Codon
Female
Genes, ras
Lymphoma
Methylnitrosourea
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Precancerous Conditions
Thymus Gland
Thymus Neoplasms

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