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Article

Follow-up of carriers of BRCA1 and BRCA2 variants of unknown significance: variant reclassification and surgical decisions.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Dec 2011

Murray Mitzi L, Cerrato Felecia, Bennett Robin L, Jarvik Gail P

Abstract excerpt

PURPOSE: : Approximately 5-10% of patients who undergo genetic testing of BRCA1 and BRCA2 receive a variant of unknown significance (VUS) result. The ambiguous nature of a VUS may increase difficulty in patient understanding and decision making regarding risk reduction and surveillance options, including cancer risk-reducing surgeries. VUS reclassification to benign or deleterious may occur in time; however,...

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Source

Identifiers

PMID: 21811163
DOI: 10.1097/GIM.0b013e318226fc15

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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