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Article

Clinical Decision-Making in Patients with Variant of Uncertain Significance in BRCA1 or BRCA2 Genes.

Annals of surgical oncology - 1 Oct 2017

Welsh Jessemae L, Hoskin Tanya L, Day Courtney N, Thomas Abigail S, Cogswell Jodie A, Couch Fergus J, Boughey Judy C

Abstract excerpt

BACKGROUND: How diagnosis with a variant of uncertain significance (VUS) in a BRCA gene impacts clinical decision-making is not well known. METHODS: We queried for all patients attending Mayo Clinic Rochester from 2004 to 2016 who tested positive for BRCA1 or BRCA2 VUS and reviewed patient management choices. Groups were compared by using Wilcoxon rank-sum and Chi-square tests. RESULTS: We identified 97 patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28766224
DOI: 10.1245/s10434-017-5959-3
PMCID: PMC6171336

Genes

BRCA1
BRCA2
CPM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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