Article
How does re-classification of variants of unknown significance (VUS) impact the management of patients at risk for hereditary breast cancer?
BMC medical genomics - 31 May 2022
Kwong Ava, Ho Cecilia Yuen Sze, Shin Vivian Yvonne, Au Chun Hang, Chan Tsun-Leung, Ma Edmond Shiu Kwan
Abstract excerpt
BACKGROUND: The popularity of multigene testing increases the probability of identifying variants of uncertain significance (VUS). While accurate variant interpretation enables clinicians to be better informed of the genetic risk of their patients, currently, there is a lack of consensus management guidelines for clinicians on VUS. METHODS: Among the BRCA1 and BRCA2 mutations screening in 3,544 subjects, 236...
Topics
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Humans
- Ovarian Neoplasms