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Germline Variants of Uncertain Significance in Gynecologic Oncology Patients.

Clinical obstetrics and gynecology - 1 Dec 2024

Cooper Julia, Senter Leigha

Abstract excerpt

Germline and somatic genetic/genomic testing are commonly ordered for gynecologic oncology patients. Genetic tests can inform disease etiology, prognosis, treatment decisions, and risk to the patient's relatives. Variants of uncertain significance (VUSs) are frequently encountered and have a more nuanced interpretation than straightforward pathogenic or benign variant classifications. Clinical care providers...

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PMID: 39324968
DOI: 10.1097/GRF.0000000000000898

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