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Article

Factors predicting reclassification of variants of unknown significance.

American journal of surgery - 1 Dec 2018

Wright Moriah, Menon Vijay, Taylor Lindsay, Shashidharan Maniamparampil, Westercamp Twilla, Ternent Charles A

Abstract excerpt

Genetic variants of unknown significance (VUS) are an increasingly common result of genetic testing. VUS present dilemmas for treatment and surveillance. Family history may play a role in VUS reclassification over time. METHODS: All genetic tests performed at a tertiary referral center 2006-2015 were evaluated for the presence of VUS. Patients with VUS were evaluated for demographics, clinical characteristics,...

Topics

Genetic Predisposition to Disease
Genetic Testing
Genetic Variation
Humans
Uncertainty

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30217367
DOI: 10.1016/j.amjsurg.2018.08.008

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