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Article

A multicenter study of clinical impact of variant of uncertain significance reclassification in breast, ovarian and colorectal cancer susceptibility genes.

Cancer medicine - 1 Feb 2023

Makhnoon Sukh, Levin Brooke, Ensinger Megan, Mattie Kristin, Volk Robert J, Zhao Zhongming, Mendoza Tito, Shete Sanjay, Samiian Laila, Grana Generosa, Grainger Andrew, Arun Banu, Shirts Brian H, Peterson Susan K

Abstract excerpt

BACKGROUND: Clinical interpretation of genetic test results is complicated by variants of uncertain significance (VUS) that have an unknown impact on health but can be clarified through reclassification. There is little empirical evidence regarding VUS reclassification in oncology care settings, including the prevalence and outcomes of reclassification, and racial/ethnic differences. METHODS: This was a...

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Identifiers

PMID: 36426404
DOI: 10.1002/cam4.5202
PMCID: PMC9939195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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