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Article

Variants of uncertain significance in BRCA testing: evaluation of surgical decisions, risk perception, and cancer distress.

Clinical genetics - 1 Nov 2013

Culver J O, Brinkerhoff C D, Clague J, Yang K, Singh K E, Sand S R, Weitzel J N

Abstract excerpt

Studies suggest that patients carrying a BRCA variant of uncertain significance (VUS) may have lingering confusion concerning results interpretation. Counseling for uninformative BRCA-negative (UN) results is thought to be more straightforward, despite the fact that both results lead to similar methods of empiric cancer risk counseling. This study compared surgical choices and perceptions between 71 patients with...

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Identifiers

PMID: 23323793
DOI: 10.1111/cge.12097
PMCID: PMC3751990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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