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Article

BRCA1 and BRCA2 genetic testing-pitfalls and recommendations for managing variants of uncertain clinical significance.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2015

Eccles D M, Mitchell G, Monteiro A N A, Schmutzler R, Couch F J, Spurdle A B, Gómez-García E B

Abstract excerpt

BACKGROUND: Increasing use of BRCA1/2 testing for tailoring cancer treatment and extension of testing to tumour tissue for somatic mutation is moving BRCA1/2 mutation screening from a primarily prevention arena delivered by specialist genetic services into mainstream oncology practice. A considerable number of gene tests will identify rare variants where clinical significance cannot be inferred from sequence...

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Identifiers

PMID: 26153499
DOI: 10.1093/annonc/mdv278
PMCID: PMC5006185

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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