Article
Synergistic actions of picibanil (OK-432) on recombinant interleukin-2 induction of tumor-infiltrating lymphocyte expansion, cytotoxicity, and phenotypic differentiation.
Journal of biological response modifiers - 1 Feb 1990
Lafreniere R, Borkenhagen K, Bryant L D, Ng E, Hayton S
Abstract excerpt
Tumor-infiltrating lymphocytes (TILs) comprise a subpopulation of lymphoid cells that infiltrate into growing tumors. These cells can be activated in vitro with recombinant interleukin-2 (rIL-2) to become highly cytotoxic against fresh tumor targets in vitro and against a variety of systemic meta...
Topics
- Animals
- Biological Products
- Cell Differentiation
- Cell Division
- Chromium Radioisotopes
- Cytotoxicity Tests, Immunologic
- Drug Synergism
- Female
- Fluorescent Antibody Technique
- Interleukin-2
- Mice
- Mice, Inbred C57BL
- Phenotype
- Picibanil
- Recombinant Proteins
- T-Lymphocytes, Cytotoxic