Article
Effects of escalating doses of recombinant human interleukin-2 in correcting functional T-cell defects following autologous bone marrow transplantation for lymphomas and solid tumors.
Experimental hematology - 1 Sept 1992
Bosly A, Guillaume T, Brice P, Humblet Y, Staquet P, Doyen C, Chatelain B, Franks C R, Gisselbrecht C, Symann M
Abstract excerpt
High-dose chemotherapy followed by autologous bone marrow transplantation (ABMT) in the treatment of malignancies is often associated with immune deficiency following transplantation, possibly contributing to tumor relapse or fatal infection. Interleukin 2 (IL-2), which enhances major histocompat...
Topics
- Adult
- Antigens, Differentiation, T-Lymphocyte
- Blood Cell Count
- Bone Marrow Transplantation
- CD2 Antigens
- CD8 Antigens
- Carcinoma, Small Cell
- Cell Death
- Cell Division
- Choriocarcinoma
- Dose-Response Relationship, Drug
- Female
- Humans