Article
Characterization of OKT3-initiated lymphokine-activated effectors expanded with interleukin 2 and tumor necrosis factor alpha.
Cancer research - 15 Jun 1990
Yang S C, Owen-Schaub L B, Roth J A, Grimm E A
Abstract excerpt
Synergistic and cooperative effects in vitro of OKT3, interleukin 2 (IL-2), and tumor necrosis factor alpha (TNF) as stimuli in generating effectors with lymphokine-activated killer activity were studied. Activation of human peripheral blood mononuclear cells with OKT3 (10 ng/ml) for 48 h, follow...
Topics
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- Cell Survival
- Drug Synergism
- Humans
- Immunotherapy
- Interleukin-2
- Killer Cells, Lymphokine-Activated
- Leukocyte Count
- Lung Neoplasms
- Lymphocyte Activation
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Cell Surface
- Receptors, Interleukin-2
- Receptors, Tumor Necrosis Factor
- Time Factors
- Tumor Cells, Cultured