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Article

Histone H3-variant Cse4-induced positive DNA supercoiling in the yeast plasmid has implications for a plasmid origin of a chromosome centromere.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2011

Huang Chu-Chun, Chang Keng-Ming, Cui Hong, Jayaram Makkuni

Abstract excerpt

The Saccharomyces cerevisiae 2-μm plasmid is a multicopy selfish genome that resides in the nucleus. The genetic organization of the plasmid is optimized for stable, high-copy propagation in host-cell populations. The plasmid's partitioning system poaches host factors, including the centromere-specific histone H3-variant Cse4 and the cohesin complex, enabling replicated plasmid copies to segregate equally in a...

Topics

Biological Evolution
Centromere
Chromosomal Proteins, Non-Histone
Chromosomes
DNA, Superhelical
DNA-Binding Proteins
Genetic Variation
Histones
Plasmids
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 21807992
DOI: 10.1073/pnas.1101944108
PMCID: PMC3158187

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Histone H3-variant Cse4-induced positive DNA supercoiling in the yeast plasmid has implications for a plasmid origin of a chromosome centromere.PMID 21807992Read ↗

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