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Article

Histone H3-variant Cse4-induced positive DNA supercoiling in the yeast plasmid has implications for a plasmid origin of a chromosome centromere.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2011

Huang Chu-Chun, Chang Keng-Ming, Cui Hong, Jayaram Makkuni

Abstract excerpt

The Saccharomyces cerevisiae 2-μm plasmid is a multicopy selfish genome that resides in the nucleus. The genetic organization of the plasmid is optimized for stable, high-copy propagation in host-cell populations. The plasmid's partitioning system poaches host factors, including the centromere-specific histone H3-variant Cse4 and the cohesin complex, enabling replicated plasmid copies to segregate equally in a...

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Identifiers

PMID: 21807992
DOI: 10.1073/pnas.1101944108
PMCID: PMC3158187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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