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Article

An asymmetric centromeric nucleosome.

eLife - 23 Aug 2018

Ichikawa Yuichi, Saitoh Noriko, Kaufman Paul D

Abstract excerpt

Nucleosomes contain two copies of each core histone, held together by a naturally symmetric, homodimeric histone H3-H3 interface. This symmetry has complicated efforts to determine the regulatory potential of this architecture. Through molecular design and in vivo selection, we recently generated obligately heterodimeric H3s, providing a powerful tool for discovery of the degree to which nucleosome symmetry...

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Identifiers

PMID: 30136924
DOI: 10.7554/eLife.37911
PMCID: PMC6125124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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