Article
High Throughput Analyses of Budding Yeast ARSs Reveal New DNA Elements Capable of Conferring Centromere-Independent Plasmid Propagation.
G3 (Bethesda, Md.) - 7 Apr 2016
Hoggard Timothy, Liachko Ivan, Burt Cassaundra, Meikle Troy, Jiang Katherine, Craciun Gheorghe, Dunham Maitreya J, Fox Catherine A
Abstract excerpt
The ability of plasmids to propagate in Saccharomyces cerevisiae has been instrumental in defining eukaryotic chromosomal control elements. Stable propagation demands both plasmid replication, which requires a chromosomal replication origin (i.e., an ARS), and plasmid distribution to dividing cells, which requires either a chromosomal centromere for segregation or a plasmid-partitioning element. While our...
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