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Article

Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.

Diabetes - 1 Apr 2018

Smith Mia J, Rihanek Marynette, Wasserfall Clive, Mathews Clayton E, Atkinson Mark A, Gottlieb Peter A, Cambier John C

Abstract excerpt

Although B cells reactive with islet autoantigens are silenced by tolerance mechanisms in healthy individuals, they can become activated and contribute to the development of type 1 diabetes. We previously demonstrated that high-affinity insulin-binding B cells (IBCs) occur exclusively in the anergic (BND) compartment in peripheral blood of healthy subjects. Consistent with their activation early in disease...

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Topics

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Share to Autoantibodies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

Source

Open in PubMed Open full text

Identifiers

PMID: 29343548
DOI: 10.2337/db17-0937
PMCID: PMC5860860

Genes

IKZF3
INS
PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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