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Article

PTPN22: setting thresholds for autoimmunity.

Seminars in immunology - 1 Aug 2006

Gregersen Peter K, Lee Hye-Soon, Batliwalla Franak, Begovich Ann B

Abstract excerpt

The 620W allelic variant of the intracellular tyrosine phosphatase, PTPN22, is associated with a number of different autoimmune disorders, and this provides direct evidence for common mechanisms underlying many of these diseases. The associated allele appears to influence thresholds for T cell re...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Share to Receptors, Antigen, T-Cell

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Source

Identifiers

PMID: 16731003
DOI: 10.1016/j.smim.2006.03.009

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16731003-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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PTPN22: setting thresholds for autoimmunity.PMID 16731003Read ↗

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The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human.Semantic proximity Read ↗

Regulation of T Cell Signaling and Immune Responses by PTPN22.Semantic proximity Read ↗

PTPN22: the archetypal non-HLA autoimmunity gene.Semantic proximity Read ↗

Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond.Semantic proximity Read ↗

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

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