Article
Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2012
Habib Tania, Funk Andrew, Rieck Mary, Brahmandam Archana, Dai Xuezhi, Panigrahi Anil K, Luning Prak Eline T, Meyer-Bahlburg Almut, Sanda Srinath, Greenbaum Carla, Rawlings David J, Buckner Jane H
Abstract excerpt
The PTPN22 genetic variant 1858T, encoding Lyp620W, is associated with multiple autoimmune disorders for which the production of autoantibodies is a common feature, suggesting a loss of B cell tolerance. Lyp620W results in blunted BCR signaling in memory B cells. Because BCR signal strength is tightly coupled to central and peripheral tolerance, we examined whether Lyp620W impacts peripheral B cell homeostasis in...
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